Row |
Level |
Rule Name |
Subject |
Property |
Value |
0 |
ERROR |
duplicate_definition |
ARO:3003556 |
IAO:0000115 |
This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. |
1 |
ERROR |
duplicate_definition |
ARO:3003557 |
IAO:0000115 |
This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. |
2 |
ERROR |
duplicate_definition |
ARO:3004607 |
IAO:0000115 |
The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. |
3 |
ERROR |
duplicate_definition |
ARO:3004609 |
IAO:0000115 |
The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. |
4 |
ERROR |
duplicate_definition |
ARO:3004610 |
IAO:0000115 |
The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. |
5 |
ERROR |
duplicate_definition |
ARO:3007561 |
IAO:0000115 |
The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. |
6 |
ERROR |
duplicate_definition |
ARO:3007562 |
IAO:0000115 |
The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. |
7 |
ERROR |
duplicate_definition |
ARO:3007787 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
8 |
ERROR |
duplicate_definition |
ARO:3007788 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
9 |
ERROR |
duplicate_definition |
ARO:3007789 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
10 |
ERROR |
duplicate_definition |
ARO:3007790 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
11 |
ERROR |
duplicate_definition |
ARO:3007791 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
12 |
ERROR |
duplicate_definition |
ARO:3007774 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
13 |
ERROR |
duplicate_definition |
ARO:3007775 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
14 |
ERROR |
duplicate_definition |
ARO:3007776 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
15 |
ERROR |
duplicate_definition |
ARO:3007777 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
16 |
ERROR |
duplicate_definition |
ARO:3007778 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
17 |
ERROR |
duplicate_definition |
ARO:3000837 |
IAO:0000115 |
SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. |
18 |
ERROR |
duplicate_definition |
ARO:3003383 |
IAO:0000115 |
SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. |
19 |
ERROR |
duplicate_definition |
ARO:3003511 |
IAO:0000115 |
SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. |
20 |
ERROR |
duplicate_definition |
ARO:3003263 |
IAO:0000115 |
Sensitive form of 16s susceptible to antibiotics. |
21 |
ERROR |
duplicate_definition |
ARO:3003264 |
IAO:0000115 |
Sensitive form of 16s susceptible to antibiotics. |
22 |
ERROR |
duplicate_definition |
ARO:3003265 |
IAO:0000115 |
Sensitive form of 16s susceptible to antibiotics. |
23 |
ERROR |
duplicate_definition |
ARO:3003262 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
24 |
ERROR |
duplicate_definition |
ARO:3003520 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
25 |
ERROR |
duplicate_definition |
ARO:3003521 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
26 |
ERROR |
duplicate_definition |
ARO:3003522 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
27 |
ERROR |
duplicate_definition |
ARO:3003523 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
28 |
ERROR |
duplicate_definition |
ARO:3003524 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
29 |
ERROR |
duplicate_definition |
ARO:3003525 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
30 |
ERROR |
duplicate_definition |
ARO:3003526 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
31 |
ERROR |
duplicate_definition |
ARO:3003527 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
32 |
ERROR |
duplicate_definition |
ARO:3003528 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
33 |
ERROR |
duplicate_definition |
ARO:3003529 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
34 |
ERROR |
duplicate_definition |
ARO:3003530 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
35 |
ERROR |
duplicate_definition |
ARO:3004108 |
IAO:0000115 |
rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. |
36 |
ERROR |
duplicate_definition |
ARO:3004109 |
IAO:0000115 |
rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. |
37 |
ERROR |
duplicate_definition |
ARO:3003922 |
IAO:0000115 |
RND efflux pump conferring resistance to fluoroquinolone. |
38 |
ERROR |
duplicate_definition |
ARO:3003923 |
IAO:0000115 |
RND efflux pump conferring resistance to fluoroquinolone. |
39 |
ERROR |
duplicate_definition |
ARO:3000824 |
IAO:0000115 |
RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. |
40 |
ERROR |
duplicate_definition |
ARO:3003379 |
IAO:0000115 |
RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. |
41 |
ERROR |
duplicate_definition |
ARO:3003380 |
IAO:0000115 |
RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. |
42 |
ERROR |
duplicate_definition |
ARO:3007616 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
43 |
ERROR |
duplicate_definition |
ARO:3007617 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
44 |
ERROR |
duplicate_definition |
ARO:3007618 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
45 |
ERROR |
duplicate_definition |
ARO:3007619 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
46 |
ERROR |
duplicate_definition |
ARO:3007620 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
47 |
ERROR |
duplicate_definition |
ARO:3007621 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
48 |
ERROR |
duplicate_definition |
ARO:3007622 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
49 |
ERROR |
duplicate_definition |
ARO:3007623 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
50 |
ERROR |
duplicate_definition |
ARO:3007624 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
51 |
ERROR |
duplicate_definition |
ARO:3007625 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
52 |
ERROR |
duplicate_definition |
ARO:3007626 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
53 |
ERROR |
duplicate_definition |
ARO:3007627 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
54 |
ERROR |
duplicate_definition |
ARO:3007628 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
55 |
ERROR |
duplicate_definition |
ARO:3001232 |
IAO:0000115 |
Produced by Streptomyces venezuelae ATCC 15439. |
56 |
ERROR |
duplicate_definition |
ARO:3001233 |
IAO:0000115 |
Produced by Streptomyces venezuelae ATCC 15439. |
57 |
ERROR |
duplicate_definition |
ARO:3000226 |
IAO:0000115 |
Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. |
58 |
ERROR |
duplicate_definition |
ARO:3003415 |
IAO:0000115 |
Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. |
59 |
ERROR |
duplicate_definition |
ARO:3007307 |
IAO:0000115 |
Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. |
60 |
ERROR |
duplicate_definition |
ARO:3007308 |
IAO:0000115 |
Phosphonoacetate is an experimental inhibitor of the fosfomycin thiol transferase fosA. |
61 |
ERROR |
duplicate_definition |
ARO:3007530 |
IAO:0000115 |
PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. |
62 |
ERROR |
duplicate_definition |
ARO:3007531 |
IAO:0000115 |
PBP2x is a penicillin-binding protein and beta-lactam resistance enzyme. Mutations can cause resistance to some beta-lactam antibiotics. |
63 |
ERROR |
duplicate_definition |
ARO:3003313 |
IAO:0000115 |
ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. |
64 |
ERROR |
duplicate_definition |
ARO:3003430 |
IAO:0000115 |
ParE is a subunit of topoisomerase IV, necessary for cell survival. Point mutations in ParE prevent fluoroquinolones from inhibiting DNA synthesis, thus conferring resistance. |
65 |
ERROR |
duplicate_definition |
ARO:3003890 |
IAO:0000115 |
Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. |
66 |
ERROR |
duplicate_definition |
ARO:3003902 |
IAO:0000115 |
Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. |
67 |
ERROR |
duplicate_definition |
ARO:3002811 |
IAO:0000115 |
murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. |
68 |
ERROR |
duplicate_definition |
ARO:3003776 |
IAO:0000115 |
murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance. |
69 |
ERROR |
duplicate_definition |
ARO:3003548 |
IAO:0000115 |
Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. |
70 |
ERROR |
duplicate_definition |
ARO:3003549 |
IAO:0000115 |
Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. |
71 |
ERROR |
duplicate_definition |
ARO:3003550 |
IAO:0000115 |
Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. |
72 |
ERROR |
duplicate_definition |
ARO:3003770 |
IAO:0000115 |
MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. |
73 |
ERROR |
duplicate_definition |
ARO:3003772 |
IAO:0000115 |
MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. |
74 |
ERROR |
duplicate_definition |
ARO:3003773 |
IAO:0000115 |
MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. |
75 |
ERROR |
duplicate_definition |
ARO:3003774 |
IAO:0000115 |
MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins. |
76 |
ERROR |
duplicate_definition |
ARO:3000718 |
IAO:0000115 |
MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. |
77 |
ERROR |
duplicate_definition |
ARO:3003378 |
IAO:0000115 |
MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB. |
78 |
ERROR |
duplicate_definition |
ARO:3003079 |
IAO:0000115 |
liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. |
79 |
ERROR |
duplicate_definition |
ARO:3003791 |
IAO:0000115 |
liaS is a histidine kinase found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. |
80 |
ERROR |
duplicate_definition |
ARO:3003078 |
IAO:0000115 |
liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. |
81 |
ERROR |
duplicate_definition |
ARO:3003792 |
IAO:0000115 |
liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance. |
82 |
ERROR |
duplicate_definition |
ARO:3003077 |
IAO:0000115 |
liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. |
83 |
ERROR |
duplicate_definition |
ARO:3003790 |
IAO:0000115 |
liaF is an accessory protein that acts as a negative regulator of liaRS signal transduction pathway. Mutations confer daptomycin resistance. |
84 |
ERROR |
duplicate_definition |
ARO:3000710 |
IAO:0000115 |
Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. |
85 |
ERROR |
duplicate_definition |
ARO:3003273 |
IAO:0000115 |
Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. |
86 |
ERROR |
duplicate_definition |
ARO:3000359 |
IAO:0000115 |
In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. |
87 |
ERROR |
duplicate_definition |
ARO:3000423 |
IAO:0000115 |
In the presence of ATP and magnesium (II), fosfomycin gets phosphorylated at the phosphate group resulting in a diphosphate group which inactivates the antibiotic. |
88 |
ERROR |
duplicate_definition |
ARO:3000263 |
IAO:0000115 |
In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. |
89 |
ERROR |
duplicate_definition |
ARO:3000265 |
IAO:0000115 |
In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF. |
90 |
ERROR |
duplicate_definition |
ARO:3005012 |
IAO:0000115 |
IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. |
91 |
ERROR |
duplicate_definition |
ARO:3005013 |
IAO:0000115 |
IDC-2 is an IDC beta-lactamase and an integron cephalosprinase. |
92 |
ERROR |
duplicate_definition |
ARO:3004672 |
IAO:0000115 |
Fosfomycin resistance gene. High homology with FosB1 and FosB3. |
93 |
ERROR |
duplicate_definition |
ARO:3004673 |
IAO:0000115 |
Fosfomycin resistance gene. High homology with FosB1 and FosB3. |
94 |
ERROR |
duplicate_definition |
ARO:3007582 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
95 |
ERROR |
duplicate_definition |
ARO:3007583 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
96 |
ERROR |
duplicate_definition |
ARO:3007584 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
97 |
ERROR |
duplicate_definition |
ARO:3007585 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
98 |
ERROR |
duplicate_definition |
ARO:3007586 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
99 |
ERROR |
duplicate_definition |
ARO:3007587 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
100 |
ERROR |
duplicate_definition |
ARO:3007588 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
101 |
ERROR |
duplicate_definition |
ARO:3007589 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
102 |
ERROR |
duplicate_definition |
ARO:3007590 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
103 |
ERROR |
duplicate_definition |
ARO:3007591 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
104 |
ERROR |
duplicate_definition |
ARO:3007592 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
105 |
ERROR |
duplicate_definition |
ARO:3007593 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
106 |
ERROR |
duplicate_definition |
ARO:3007594 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
107 |
ERROR |
duplicate_definition |
ARO:3007595 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
108 |
ERROR |
duplicate_definition |
ARO:3007596 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
109 |
ERROR |
duplicate_definition |
ARO:3007597 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
110 |
ERROR |
duplicate_definition |
ARO:3007598 |
IAO:0000115 |
Formicamycin congeners are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. |
111 |
ERROR |
duplicate_definition |
ARO:3007575 |
IAO:0000115 |
Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. |
112 |
ERROR |
duplicate_definition |
ARO:3007576 |
IAO:0000115 |
Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. |
113 |
ERROR |
duplicate_definition |
ARO:3007577 |
IAO:0000115 |
Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. |
114 |
ERROR |
duplicate_definition |
ARO:3007578 |
IAO:0000115 |
Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. |
115 |
ERROR |
duplicate_definition |
ARO:3007579 |
IAO:0000115 |
Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. |
116 |
ERROR |
duplicate_definition |
ARO:3007580 |
IAO:0000115 |
Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. |
117 |
ERROR |
duplicate_definition |
ARO:3007581 |
IAO:0000115 |
Fasamycin congeners were named as such after they were shown to be inhibitors of the bacterial fatty acid synthase (FAS) condensing enzyme FabF. |
118 |
ERROR |
duplicate_definition |
ARO:3004045 |
IAO:0000115 |
fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. |
119 |
ERROR |
duplicate_definition |
ARO:3004270 |
IAO:0000115 |
fabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid. |
120 |
ERROR |
duplicate_definition |
ARO:3000495 |
IAO:0000115 |
ErmD confers MLSb phenotype. |
121 |
ERROR |
duplicate_definition |
ARO:3000599 |
IAO:0000115 |
ErmD confers MLSb phenotype. |
122 |
ERROR |
duplicate_definition |
ARO:3000600 |
IAO:0000115 |
ErmD confers MLSb phenotype. |
123 |
ERROR |
duplicate_definition |
ARO:3000601 |
IAO:0000115 |
ErmD confers MLSb phenotype. |
124 |
ERROR |
duplicate_definition |
ARO:3000602 |
IAO:0000115 |
ErmD confers MLSb phenotype. |
125 |
ERROR |
duplicate_definition |
ARO:3000604 |
IAO:0000115 |
ErmD confers MLSb phenotype. |
126 |
ERROR |
duplicate_definition |
ARO:3000605 |
IAO:0000115 |
ErmD confers MLSb phenotype. |
127 |
ERROR |
duplicate_definition |
ARO:3000733 |
IAO:0000115 |
DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. |
128 |
ERROR |
duplicate_definition |
ARO:3003254 |
IAO:0000115 |
DNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling. |
129 |
ERROR |
duplicate_definition |
ARO:3004053 |
IAO:0000115 |
CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. |
130 |
ERROR |
duplicate_definition |
ARO:3004054 |
IAO:0000115 |
CpxR is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR. |
131 |
ERROR |
duplicate_definition |
ARO:3007601 |
IAO:0000115 |
Cervimycins are polyketide antibiotics. |
132 |
ERROR |
duplicate_definition |
ARO:3007602 |
IAO:0000115 |
Cervimycins are polyketide antibiotics. |
133 |
ERROR |
duplicate_definition |
ARO:3007603 |
IAO:0000115 |
Cervimycins are polyketide antibiotics. |
134 |
ERROR |
duplicate_definition |
ARO:3007604 |
IAO:0000115 |
Cervimycins are polyketide antibiotics. |
135 |
ERROR |
duplicate_definition |
ARO:3007605 |
IAO:0000115 |
Cervimycins are polyketide antibiotics. |
136 |
ERROR |
duplicate_definition |
ARO:3007606 |
IAO:0000115 |
Cervimycins are polyketide antibiotics. |
137 |
ERROR |
duplicate_definition |
ARO:3007607 |
IAO:0000115 |
Cervimycins are polyketide antibiotics. |
138 |
ERROR |
duplicate_definition |
ARO:3007630 |
IAO:0000115 |
Cadasides are lipopeptides with antibiotic activity. |
139 |
ERROR |
duplicate_definition |
ARO:3007631 |
IAO:0000115 |
Cadasides are lipopeptides with antibiotic activity. |
140 |
ERROR |
duplicate_definition |
ARO:3005210 |
IAO:0000115 |
Beta-lactamase gene from Klebsiella pneumoniae. |
141 |
ERROR |
duplicate_definition |
ARO:3005211 |
IAO:0000115 |
Beta-lactamase gene from Klebsiella pneumoniae. |
142 |
ERROR |
duplicate_definition |
ARO:3005223 |
IAO:0000115 |
Beta-lactamase gene from Klebsiella pneumoniae. |
143 |
ERROR |
duplicate_definition |
ARO:3005224 |
IAO:0000115 |
Beta-lactamase gene from Klebsiella pneumoniae. |
144 |
ERROR |
duplicate_definition |
ARO:3005225 |
IAO:0000115 |
Beta-lactamase gene from Klebsiella pneumoniae. |
145 |
ERROR |
duplicate_definition |
ARO:3005231 |
IAO:0000115 |
Beta-lactamase gene from Klebsiella pneumoniae. |
146 |
ERROR |
duplicate_definition |
ARO:3005233 |
IAO:0000115 |
Beta-lactamase gene from Klebsiella pneumoniae. |
147 |
ERROR |
duplicate_definition |
ARO:3007227 |
IAO:0000115 |
An MCR-8-type colistin resistance gene variant. |
148 |
ERROR |
duplicate_definition |
ARO:3007228 |
IAO:0000115 |
An MCR-8-type colistin resistance gene variant. |
149 |
ERROR |
duplicate_definition |
ARO:3007229 |
IAO:0000115 |
An MCR-8-type colistin resistance gene variant. |
150 |
ERROR |
duplicate_definition |
ARO:3007281 |
IAO:0000115 |
An MCR-5-type colistin resistance gene variant. |
151 |
ERROR |
duplicate_definition |
ARO:3007282 |
IAO:0000115 |
An MCR-5-type colistin resistance gene variant. |
152 |
ERROR |
duplicate_definition |
ARO:3007231 |
IAO:0000115 |
An MCR-4-type colistin resistance gene variant. |
153 |
ERROR |
duplicate_definition |
ARO:3007533 |
IAO:0000115 |
An MCR-4-type colistin resistance gene variant. |
154 |
ERROR |
duplicate_definition |
ARO:3007248 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
155 |
ERROR |
duplicate_definition |
ARO:3007249 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
156 |
ERROR |
duplicate_definition |
ARO:3007250 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
157 |
ERROR |
duplicate_definition |
ARO:3007251 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
158 |
ERROR |
duplicate_definition |
ARO:3007252 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
159 |
ERROR |
duplicate_definition |
ARO:3007253 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
160 |
ERROR |
duplicate_definition |
ARO:3007254 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
161 |
ERROR |
duplicate_definition |
ARO:3007255 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
162 |
ERROR |
duplicate_definition |
ARO:3007256 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
163 |
ERROR |
duplicate_definition |
ARO:3007257 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
164 |
ERROR |
duplicate_definition |
ARO:3007258 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
165 |
ERROR |
duplicate_definition |
ARO:3007259 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
166 |
ERROR |
duplicate_definition |
ARO:3007260 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
167 |
ERROR |
duplicate_definition |
ARO:3007261 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
168 |
ERROR |
duplicate_definition |
ARO:3007262 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
169 |
ERROR |
duplicate_definition |
ARO:3007263 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
170 |
ERROR |
duplicate_definition |
ARO:3007264 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
171 |
ERROR |
duplicate_definition |
ARO:3007265 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
172 |
ERROR |
duplicate_definition |
ARO:3007266 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
173 |
ERROR |
duplicate_definition |
ARO:3007267 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
174 |
ERROR |
duplicate_definition |
ARO:3007268 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
175 |
ERROR |
duplicate_definition |
ARO:3007269 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
176 |
ERROR |
duplicate_definition |
ARO:3007270 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
177 |
ERROR |
duplicate_definition |
ARO:3007271 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
178 |
ERROR |
duplicate_definition |
ARO:3007272 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
179 |
ERROR |
duplicate_definition |
ARO:3007273 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
180 |
ERROR |
duplicate_definition |
ARO:3007278 |
IAO:0000115 |
An MCR-3-type colistin resistance gene variant. |
181 |
ERROR |
duplicate_definition |
ARO:3007283 |
IAO:0000115 |
An MCR-2-type colistin resistance gene variant. |
182 |
ERROR |
duplicate_definition |
ARO:3007284 |
IAO:0000115 |
An MCR-2-type colistin resistance gene variant. |
183 |
ERROR |
duplicate_definition |
ARO:3007285 |
IAO:0000115 |
An MCR-2-type colistin resistance gene variant. |
184 |
ERROR |
duplicate_definition |
ARO:3007286 |
IAO:0000115 |
An MCR-2-type colistin resistance gene variant. |
185 |
ERROR |
duplicate_definition |
ARO:3007287 |
IAO:0000115 |
An MCR-2-type colistin resistance gene variant. |
186 |
ERROR |
duplicate_definition |
ARO:3007288 |
IAO:0000115 |
An MCR-2-type colistin resistance gene variant. |
187 |
ERROR |
duplicate_definition |
ARO:3007137 |
IAO:0000115 |
An MCR-10-type colistin resistance gene variant. |
188 |
ERROR |
duplicate_definition |
ARO:3007274 |
IAO:0000115 |
An MCR-10-type colistin resistance gene variant. |
189 |
ERROR |
duplicate_definition |
ARO:3007275 |
IAO:0000115 |
An MCR-10-type colistin resistance gene variant. |
190 |
ERROR |
duplicate_definition |
ARO:3007276 |
IAO:0000115 |
An MCR-10-type colistin resistance gene variant. |
191 |
ERROR |
duplicate_definition |
ARO:3007277 |
IAO:0000115 |
An MCR-10-type colistin resistance gene variant. |
192 |
ERROR |
duplicate_definition |
ARO:3007230 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |
193 |
ERROR |
duplicate_definition |
ARO:3007232 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |
194 |
ERROR |
duplicate_definition |
ARO:3007233 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |
195 |
ERROR |
duplicate_definition |
ARO:3007234 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |
196 |
ERROR |
duplicate_definition |
ARO:3007235 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |
197 |
ERROR |
duplicate_definition |
ARO:3007236 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |
198 |
ERROR |
duplicate_definition |
ARO:3007237 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |
199 |
ERROR |
duplicate_definition |
ARO:3007238 |
IAO:0000115 |
An MCR-1-type colistin resistance gene variant. |