| Row |
Level |
Rule Name |
Subject |
Property |
Value |
| 0 |
ERROR |
duplicate_definition |
ARO:3009466 |
IAO:0000115 |
Yor1 can cause excessive efflux of azoles when mutated. |
| 1 |
ERROR |
duplicate_definition |
ARO:3009467 |
IAO:0000115 |
Yor1 can cause excessive efflux of azoles when mutated. |
| 2 |
ERROR |
duplicate_definition |
ARO:3009468 |
IAO:0000115 |
Yor1 can cause excessive efflux of azoles when mutated. |
| 3 |
ERROR |
duplicate_definition |
ARO:3009636 |
IAO:0000115 |
UPC2 encodes a transcription factor that is a master regulator of ergosterol biosynthesis in fungi. Its mutation is clinically important because gain-of-function mutations in UPC2 are a well-known mechanism of azole resistance. |
| 4 |
ERROR |
duplicate_definition |
ARO:3009637 |
IAO:0000115 |
UPC2 encodes a transcription factor that is a master regulator of ergosterol biosynthesis in fungi. Its mutation is clinically important because gain-of-function mutations in UPC2 are a well-known mechanism of azole resistance. |
| 5 |
ERROR |
duplicate_definition |
ARO:3009638 |
IAO:0000115 |
UPC2 encodes a transcription factor that is a master regulator of ergosterol biosynthesis in fungi. Its mutation is clinically important because gain-of-function mutations in UPC2 are a well-known mechanism of azole resistance. |
| 6 |
ERROR |
duplicate_definition |
ARO:3003556 |
IAO:0000115 |
This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. |
| 7 |
ERROR |
duplicate_definition |
ARO:3003557 |
IAO:0000115 |
This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properties. |
| 8 |
ERROR |
duplicate_definition |
ARO:3007692 |
IAO:0000115 |
These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine. |
| 9 |
ERROR |
duplicate_definition |
ARO:3009335 |
IAO:0000115 |
These pepQ/Rv2535c mutations increase efflux through the mmpL5-mmpS5 (Rv0676c-Rv0677c) transporter, such as preventing degradation of MmpL5, which leads to reduced susceptibility to bedaquiline and clofazimine. |
| 10 |
ERROR |
duplicate_definition |
ARO:3009200 |
IAO:0000115 |
The P450 enzyme system, which may be alternatively named the Cyp51 enzyme system in some fungi, is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to the P450/Cyp51 genes have been shown to inhibit azole activity. |
| 11 |
ERROR |
duplicate_definition |
ARO:3009202 |
IAO:0000115 |
The P450 enzyme system, which may be alternatively named the Cyp51 enzyme system in some fungi, is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to the P450/Cyp51 genes have been shown to inhibit azole activity. |
| 12 |
ERROR |
duplicate_definition |
ARO:3009203 |
IAO:0000115 |
The P450 enzyme system, which may be alternatively named the Cyp51 enzyme system in some fungi, is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to the P450/Cyp51 genes have been shown to inhibit azole activity. |
| 13 |
ERROR |
duplicate_definition |
ARO:3009260 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 14 |
ERROR |
duplicate_definition |
ARO:3009261 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 15 |
ERROR |
duplicate_definition |
ARO:3009262 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 16 |
ERROR |
duplicate_definition |
ARO:3009263 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 17 |
ERROR |
duplicate_definition |
ARO:3009264 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 18 |
ERROR |
duplicate_definition |
ARO:3009265 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 19 |
ERROR |
duplicate_definition |
ARO:3009266 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 20 |
ERROR |
duplicate_definition |
ARO:3009267 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 21 |
ERROR |
duplicate_definition |
ARO:3009296 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 22 |
ERROR |
duplicate_definition |
ARO:3009458 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 23 |
ERROR |
duplicate_definition |
ARO:3009459 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 24 |
ERROR |
duplicate_definition |
ARO:3009460 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 25 |
ERROR |
duplicate_definition |
ARO:3009461 |
IAO:0000115 |
The Mfs family of genes in fungi are responsible for a variety of transport across the cell membrane. Mutations to this family of genes can result in anti-fungal resistance, especially against azole drugs. |
| 26 |
ERROR |
duplicate_definition |
ARO:3009254 |
IAO:0000115 |
The Mdr2 gene is responsible for proteins that maintain the phospholipid bilayer permeability in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 27 |
ERROR |
duplicate_definition |
ARO:3009255 |
IAO:0000115 |
The Mdr2 gene is responsible for proteins that maintain the phospholipid bilayer permeability in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 28 |
ERROR |
duplicate_definition |
ARO:3009256 |
IAO:0000115 |
The Mdr2 gene is responsible for proteins that maintain the phospholipid bilayer permeability in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 29 |
ERROR |
duplicate_definition |
ARO:3009257 |
IAO:0000115 |
The Mdr2 gene is responsible for proteins that maintain the phospholipid bilayer permeability in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 30 |
ERROR |
duplicate_definition |
ARO:3009258 |
IAO:0000115 |
The Mdr2 gene is responsible for proteins that maintain the phospholipid bilayer permeability in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 31 |
ERROR |
duplicate_definition |
ARO:3009253 |
IAO:0000115 |
The Mdr2 gene is responsible for an MFS family of efflux pumps in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 32 |
ERROR |
duplicate_definition |
ARO:3009451 |
IAO:0000115 |
The Mdr2 gene is responsible for an MFS family of efflux pumps in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 33 |
ERROR |
duplicate_definition |
ARO:3009452 |
IAO:0000115 |
The Mdr2 gene is responsible for an MFS family of efflux pumps in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 34 |
ERROR |
duplicate_definition |
ARO:3009453 |
IAO:0000115 |
The Mdr2 gene is responsible for an MFS family of efflux pumps in fungi. Mutation in this gene can result in resistance against azole drugs. |
| 35 |
ERROR |
duplicate_definition |
ARO:3009251 |
IAO:0000115 |
The Mdr gene is responsible for synthesis of the ABC class of efflux pumps. Mutation in this gene can result in resistance against azole drugs. |
| 36 |
ERROR |
duplicate_definition |
ARO:3009252 |
IAO:0000115 |
The Mdr gene is responsible for synthesis of the ABC class of efflux pumps. Mutation in this gene can result in resistance against azole drugs. |
| 37 |
ERROR |
duplicate_definition |
ARO:3009446 |
IAO:0000115 |
The Mdr gene is responsible for synthesis of the ABC class of efflux pumps. Mutation in this gene can result in resistance against azole drugs. |
| 38 |
ERROR |
duplicate_definition |
ARO:3009447 |
IAO:0000115 |
The Mdr gene is responsible for synthesis of the ABC class of efflux pumps. Mutation in this gene can result in resistance against azole drugs. |
| 39 |
ERROR |
duplicate_definition |
ARO:3009448 |
IAO:0000115 |
The Mdr gene is responsible for synthesis of the ABC class of efflux pumps. Mutation in this gene can result in resistance against azole drugs. |
| 40 |
ERROR |
duplicate_definition |
ARO:3009249 |
IAO:0000115 |
The Mdr gene is responsible for synthesis of the ABC class of efflux pumps. Mutation in this gene can result in antifungal resistance. |
| 41 |
ERROR |
duplicate_definition |
ARO:3009297 |
IAO:0000115 |
The Mdr gene is responsible for synthesis of the ABC class of efflux pumps. Mutation in this gene can result in antifungal resistance. |
| 42 |
ERROR |
duplicate_definition |
ARO:3009230 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 43 |
ERROR |
duplicate_definition |
ARO:3009235 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 44 |
ERROR |
duplicate_definition |
ARO:3009236 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 45 |
ERROR |
duplicate_definition |
ARO:3009237 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 46 |
ERROR |
duplicate_definition |
ARO:3009366 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 47 |
ERROR |
duplicate_definition |
ARO:3009367 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 48 |
ERROR |
duplicate_definition |
ARO:3009368 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 49 |
ERROR |
duplicate_definition |
ARO:3009369 |
IAO:0000115 |
The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| 50 |
ERROR |
duplicate_definition |
ARO:3009213 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 51 |
ERROR |
duplicate_definition |
ARO:3009219 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 52 |
ERROR |
duplicate_definition |
ARO:3009220 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 53 |
ERROR |
duplicate_definition |
ARO:3009221 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 54 |
ERROR |
duplicate_definition |
ARO:3009222 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 55 |
ERROR |
duplicate_definition |
ARO:3009223 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 56 |
ERROR |
duplicate_definition |
ARO:3009225 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 57 |
ERROR |
duplicate_definition |
ARO:3009226 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 58 |
ERROR |
duplicate_definition |
ARO:3009227 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 59 |
ERROR |
duplicate_definition |
ARO:3009303 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 60 |
ERROR |
duplicate_definition |
ARO:3009393 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 61 |
ERROR |
duplicate_definition |
ARO:3009396 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 62 |
ERROR |
duplicate_definition |
ARO:3009397 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 63 |
ERROR |
duplicate_definition |
ARO:3009398 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 64 |
ERROR |
duplicate_definition |
ARO:3009399 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 65 |
ERROR |
duplicate_definition |
ARO:3009403 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 66 |
ERROR |
duplicate_definition |
ARO:3009404 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 67 |
ERROR |
duplicate_definition |
ARO:3009414 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 68 |
ERROR |
duplicate_definition |
ARO:3009415 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 69 |
ERROR |
duplicate_definition |
ARO:3009426 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 70 |
ERROR |
duplicate_definition |
ARO:3009457 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 71 |
ERROR |
duplicate_definition |
ARO:3009575 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 72 |
ERROR |
duplicate_definition |
ARO:3009578 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 73 |
ERROR |
duplicate_definition |
ARO:3009579 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 74 |
ERROR |
duplicate_definition |
ARO:3009580 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 75 |
ERROR |
duplicate_definition |
ARO:3009581 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 76 |
ERROR |
duplicate_definition |
ARO:3009582 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 77 |
ERROR |
duplicate_definition |
ARO:3009583 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 78 |
ERROR |
duplicate_definition |
ARO:3009584 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 79 |
ERROR |
duplicate_definition |
ARO:3009585 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 80 |
ERROR |
duplicate_definition |
ARO:3009587 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 81 |
ERROR |
duplicate_definition |
ARO:3009588 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 82 |
ERROR |
duplicate_definition |
ARO:3009589 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 83 |
ERROR |
duplicate_definition |
ARO:3009590 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 84 |
ERROR |
duplicate_definition |
ARO:3009591 |
IAO:0000115 |
The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| 85 |
ERROR |
duplicate_definition |
ARO:3009201 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 86 |
ERROR |
duplicate_definition |
ARO:3009204 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 87 |
ERROR |
duplicate_definition |
ARO:3009205 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 88 |
ERROR |
duplicate_definition |
ARO:3009210 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 89 |
ERROR |
duplicate_definition |
ARO:3009211 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 90 |
ERROR |
duplicate_definition |
ARO:3009282 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 91 |
ERROR |
duplicate_definition |
ARO:3009283 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 92 |
ERROR |
duplicate_definition |
ARO:3009400 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 93 |
ERROR |
duplicate_definition |
ARO:3009402 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 94 |
ERROR |
duplicate_definition |
ARO:3009406 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 95 |
ERROR |
duplicate_definition |
ARO:3009407 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 96 |
ERROR |
duplicate_definition |
ARO:3009409 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 97 |
ERROR |
duplicate_definition |
ARO:3009411 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 98 |
ERROR |
duplicate_definition |
ARO:3009490 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 99 |
ERROR |
duplicate_definition |
ARO:3009491 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 100 |
ERROR |
duplicate_definition |
ARO:3009492 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 101 |
ERROR |
duplicate_definition |
ARO:3009493 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 102 |
ERROR |
duplicate_definition |
ARO:3009494 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 103 |
ERROR |
duplicate_definition |
ARO:3009495 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 104 |
ERROR |
duplicate_definition |
ARO:3009496 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 105 |
ERROR |
duplicate_definition |
ARO:3009497 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 106 |
ERROR |
duplicate_definition |
ARO:3009498 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 107 |
ERROR |
duplicate_definition |
ARO:3009499 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 108 |
ERROR |
duplicate_definition |
ARO:3009500 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 109 |
ERROR |
duplicate_definition |
ARO:3009501 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 110 |
ERROR |
duplicate_definition |
ARO:3009502 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 111 |
ERROR |
duplicate_definition |
ARO:3009503 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 112 |
ERROR |
duplicate_definition |
ARO:3009504 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 113 |
ERROR |
duplicate_definition |
ARO:3009505 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 114 |
ERROR |
duplicate_definition |
ARO:3009506 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 115 |
ERROR |
duplicate_definition |
ARO:3009507 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 116 |
ERROR |
duplicate_definition |
ARO:3009508 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 117 |
ERROR |
duplicate_definition |
ARO:3009509 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 118 |
ERROR |
duplicate_definition |
ARO:3009510 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 119 |
ERROR |
duplicate_definition |
ARO:3009511 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 120 |
ERROR |
duplicate_definition |
ARO:3009512 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 121 |
ERROR |
duplicate_definition |
ARO:3009513 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 122 |
ERROR |
duplicate_definition |
ARO:3009514 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 123 |
ERROR |
duplicate_definition |
ARO:3009515 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 124 |
ERROR |
duplicate_definition |
ARO:3009540 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 125 |
ERROR |
duplicate_definition |
ARO:3009541 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 126 |
ERROR |
duplicate_definition |
ARO:3009542 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 127 |
ERROR |
duplicate_definition |
ARO:3009555 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 128 |
ERROR |
duplicate_definition |
ARO:3009556 |
IAO:0000115 |
The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| 129 |
ERROR |
duplicate_definition |
ARO:3009549 |
IAO:0000115 |
The cytochrome P450 enzyme family is central to several fungal metabolisms, inclusive of sterol biosynthesis. Succinate dehydrogenase inhibitor (SDHI) fungicides target the SDH complex in the mitochondrial electron transport chain, blocking respiration and ATP production. Although SDHIs do not directly target P450 enzymes, mutations or altered expression in certain fungal P450s can affect drug detoxification and cellular metabolism, thereby contributing to conferred resistance. |
| 130 |
ERROR |
duplicate_definition |
ARO:3009550 |
IAO:0000115 |
The cytochrome P450 enzyme family is central to several fungal metabolisms, inclusive of sterol biosynthesis. Succinate dehydrogenase inhibitor (SDHI) fungicides target the SDH complex in the mitochondrial electron transport chain, blocking respiration and ATP production. Although SDHIs do not directly target P450 enzymes, mutations or altered expression in certain fungal P450s can affect drug detoxification and cellular metabolism, thereby contributing to conferred resistance. |
| 131 |
ERROR |
duplicate_definition |
ARO:3009551 |
IAO:0000115 |
The cytochrome P450 enzyme family is central to several fungal metabolisms, inclusive of sterol biosynthesis. Succinate dehydrogenase inhibitor (SDHI) fungicides target the SDH complex in the mitochondrial electron transport chain, blocking respiration and ATP production. Although SDHIs do not directly target P450 enzymes, mutations or altered expression in certain fungal P450s can affect drug detoxification and cellular metabolism, thereby contributing to conferred resistance. |
| 132 |
ERROR |
duplicate_definition |
ARO:3009545 |
IAO:0000115 |
The cytochrome P450 enzyme Cyp51 is central to fungal ergosterol production. Strobilurin fungicides act on the mitochondrial respiratory chain by binding to the Qo site of cytochrome b, thereby inhibiting electron transport and ATP synthesis. Although strobilurins do not directly target Cyp51, mutations in Cyp51 and other sterol biosynthesis genes can influence overall fungal fitness and occasionally contribute to conferred resistance to other drug classes such as strobilurins. |
| 133 |
ERROR |
duplicate_definition |
ARO:3009548 |
IAO:0000115 |
The cytochrome P450 enzyme Cyp51 is central to fungal ergosterol production. Strobilurin fungicides act on the mitochondrial respiratory chain by binding to the Qo site of cytochrome b, thereby inhibiting electron transport and ATP synthesis. Although strobilurins do not directly target Cyp51, mutations in Cyp51 and other sterol biosynthesis genes can influence overall fungal fitness and occasionally contribute to conferred resistance to other drug classes such as strobilurins. |
| 134 |
ERROR |
duplicate_definition |
ARO:3004607 |
IAO:0000115 |
The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. |
| 135 |
ERROR |
duplicate_definition |
ARO:3004609 |
IAO:0000115 |
The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. |
| 136 |
ERROR |
duplicate_definition |
ARO:3004610 |
IAO:0000115 |
The cfr groups were determined by Candela et al (2017) by determining the phylogenetic relationship using the neighbour-joining method to compare the cfr-like proteins to cfr. |
| 137 |
ERROR |
duplicate_definition |
ARO:3007561 |
IAO:0000115 |
The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. |
| 138 |
ERROR |
duplicate_definition |
ARO:3007562 |
IAO:0000115 |
The blaOXA-48-like enzyme demonstrated significant hydrolysis activity against meropenem, and the classical beta-lactamase inhibitor had no significant inhibitory effect. This is a novel OXA carbapenemases in S. xiamenensis. |
| 139 |
ERROR |
duplicate_definition |
ARO:3009271 |
IAO:0000115 |
The ase1 gene encodes a microtubule associated protein that is particularly involved in the mitotic spindle formation and stabilization during cell division. Alterations in cell division can often lead to major genetic adaptations, such as the development of aneuploidy. In instances where a fungi can survive a major genetic adaptation, the resultant mutant could exhibit antifungal resistance. |
| 140 |
ERROR |
duplicate_definition |
ARO:3009272 |
IAO:0000115 |
The ase1 gene encodes a microtubule associated protein that is particularly involved in the mitotic spindle formation and stabilization during cell division. Alterations in cell division can often lead to major genetic adaptations, such as the development of aneuploidy. In instances where a fungi can survive a major genetic adaptation, the resultant mutant could exhibit antifungal resistance. |
| 141 |
ERROR |
duplicate_definition |
ARO:3009273 |
IAO:0000115 |
The ase1 gene encodes a microtubule associated protein that is particularly involved in the mitotic spindle formation and stabilization during cell division. Alterations in cell division can often lead to major genetic adaptations, such as the development of aneuploidy. In instances where a fungi can survive a major genetic adaptation, the resultant mutant could exhibit antifungal resistance. |
| 142 |
ERROR |
duplicate_definition |
ARO:3009274 |
IAO:0000115 |
The ase1 gene encodes a microtubule associated protein that is particularly involved in the mitotic spindle formation and stabilization during cell division. Alterations in cell division can often lead to major genetic adaptations, such as the development of aneuploidy. In instances where a fungi can survive a major genetic adaptation, the resultant mutant could exhibit antifungal resistance. |
| 143 |
ERROR |
duplicate_definition |
ARO:3009295 |
IAO:0000115 |
The ase1 gene encodes a microtubule associated protein that is particularly involved in the mitotic spindle formation and stabilization during cell division. Alterations in cell division can often lead to major genetic adaptations, such as the development of aneuploidy. In instances where a fungi can survive a major genetic adaptation, the resultant mutant could exhibit antifungal resistance. |
| 144 |
ERROR |
duplicate_definition |
ARO:3007787 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
| 145 |
ERROR |
duplicate_definition |
ARO:3007788 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
| 146 |
ERROR |
duplicate_definition |
ARO:3007789 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
| 147 |
ERROR |
duplicate_definition |
ARO:3007790 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
| 148 |
ERROR |
duplicate_definition |
ARO:3007791 |
IAO:0000115 |
Tartrolons are a group of boron-containing (excluding tartrolon A) macrolide antibiotics discovered in 1994 from the culture broth of the myxobacterium Sorangium cellulosum. |
| 149 |
ERROR |
duplicate_definition |
ARO:3009278 |
IAO:0000115 |
Strobilurins, also known as QOI fungicides, are a group of fungicides originally isolated from the fungus Strobilurus tenacellus that inhibit mitochondrial respiration by binding to Complex III in the electron transport chain thereby disrupting the fungus's ability to produce energy. |
| 150 |
ERROR |
duplicate_definition |
ARO:3009304 |
IAO:0000115 |
Strobilurins, also known as QOI fungicides, are a group of fungicides originally isolated from the fungus Strobilurus tenacellus that inhibit mitochondrial respiration by binding to Complex III in the electron transport chain thereby disrupting the fungus's ability to produce energy. |
| 151 |
ERROR |
duplicate_definition |
ARO:3009305 |
IAO:0000115 |
Strobilurins, also known as QOI fungicides, are a group of fungicides originally isolated from the fungus Strobilurus tenacellus that inhibit mitochondrial respiration by binding to Complex III in the electron transport chain thereby disrupting the fungus's ability to produce energy. |
| 152 |
ERROR |
duplicate_definition |
ARO:3009268 |
IAO:0000115 |
Squalene epoxidase is a vital enzyme in the fungal system that matures sterols into ergosterol. Mutations to this enzyme can result in antifungal resistance. |
| 153 |
ERROR |
duplicate_definition |
ARO:3009269 |
IAO:0000115 |
Squalene epoxidase is a vital enzyme in the fungal system that matures sterols into ergosterol. Mutations to this enzyme can result in antifungal resistance. |
| 154 |
ERROR |
duplicate_definition |
ARO:3009270 |
IAO:0000115 |
Squalene epoxidase is a vital enzyme in the fungal system that matures sterols into ergosterol. Mutations to this enzyme can result in antifungal resistance. |
| 155 |
ERROR |
duplicate_definition |
ARO:3007774 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
| 156 |
ERROR |
duplicate_definition |
ARO:3007775 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
| 157 |
ERROR |
duplicate_definition |
ARO:3007776 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
| 158 |
ERROR |
duplicate_definition |
ARO:3007777 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
| 159 |
ERROR |
duplicate_definition |
ARO:3007778 |
IAO:0000115 |
Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
| 160 |
ERROR |
duplicate_definition |
ARO:3000837 |
IAO:0000115 |
SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. |
| 161 |
ERROR |
duplicate_definition |
ARO:3003383 |
IAO:0000115 |
SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. |
| 162 |
ERROR |
duplicate_definition |
ARO:3003511 |
IAO:0000115 |
SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability. |
| 163 |
ERROR |
duplicate_definition |
ARO:3003263 |
IAO:0000115 |
Sensitive form of 16s susceptible to antibiotics. |
| 164 |
ERROR |
duplicate_definition |
ARO:3003264 |
IAO:0000115 |
Sensitive form of 16s susceptible to antibiotics. |
| 165 |
ERROR |
duplicate_definition |
ARO:3003265 |
IAO:0000115 |
Sensitive form of 16s susceptible to antibiotics. |
| 166 |
ERROR |
duplicate_definition |
ARO:3003262 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 167 |
ERROR |
duplicate_definition |
ARO:3003520 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 168 |
ERROR |
duplicate_definition |
ARO:3003521 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 169 |
ERROR |
duplicate_definition |
ARO:3003522 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 170 |
ERROR |
duplicate_definition |
ARO:3003523 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 171 |
ERROR |
duplicate_definition |
ARO:3003524 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 172 |
ERROR |
duplicate_definition |
ARO:3003525 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 173 |
ERROR |
duplicate_definition |
ARO:3003526 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 174 |
ERROR |
duplicate_definition |
ARO:3003527 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 175 |
ERROR |
duplicate_definition |
ARO:3003528 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 176 |
ERROR |
duplicate_definition |
ARO:3003529 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 177 |
ERROR |
duplicate_definition |
ARO:3003530 |
IAO:0000115 |
Sensitive form of 16s susceptable to antibiotics. |
| 178 |
ERROR |
duplicate_definition |
ARO:3004108 |
IAO:0000115 |
rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. |
| 179 |
ERROR |
duplicate_definition |
ARO:3004109 |
IAO:0000115 |
rob is a positive regulator for the acrAB efflux genes, and is structurally similar to SoxS and MarA. |
| 180 |
ERROR |
duplicate_definition |
ARO:3003922 |
IAO:0000115 |
RND efflux pump conferring resistance to fluoroquinolone. |
| 181 |
ERROR |
duplicate_definition |
ARO:3003923 |
IAO:0000115 |
RND efflux pump conferring resistance to fluoroquinolone. |
| 182 |
ERROR |
duplicate_definition |
ARO:3000824 |
IAO:0000115 |
RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. |
| 183 |
ERROR |
duplicate_definition |
ARO:3003379 |
IAO:0000115 |
RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. |
| 184 |
ERROR |
duplicate_definition |
ARO:3003380 |
IAO:0000115 |
RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. |
| 185 |
ERROR |
duplicate_definition |
ARO:3007616 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 186 |
ERROR |
duplicate_definition |
ARO:3007617 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 187 |
ERROR |
duplicate_definition |
ARO:3007618 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 188 |
ERROR |
duplicate_definition |
ARO:3007619 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 189 |
ERROR |
duplicate_definition |
ARO:3007620 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 190 |
ERROR |
duplicate_definition |
ARO:3007621 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 191 |
ERROR |
duplicate_definition |
ARO:3007622 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 192 |
ERROR |
duplicate_definition |
ARO:3007623 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 193 |
ERROR |
duplicate_definition |
ARO:3007624 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 194 |
ERROR |
duplicate_definition |
ARO:3007625 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 195 |
ERROR |
duplicate_definition |
ARO:3007626 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 196 |
ERROR |
duplicate_definition |
ARO:3007627 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 197 |
ERROR |
duplicate_definition |
ARO:3007628 |
IAO:0000115 |
Pyrrolomycins are protonophores with antibiotic activity. |
| 198 |
ERROR |
duplicate_definition |
ARO:3001232 |
IAO:0000115 |
Produced by Streptomyces venezuelae ATCC 15439. |
| 199 |
ERROR |
duplicate_definition |
ARO:3001233 |
IAO:0000115 |
Produced by Streptomyces venezuelae ATCC 15439. |