Level Rule Name Subject Property Value ERROR duplicate_definition INO:0000072 IAO:0000115 a regulation of transcription by binding to promoter that is further classified as a positive regulation ERROR duplicate_definition INO:0000074 IAO:0000115 a regulation of transcription by binding to promoter that is further classified as a positive regulation ERROR duplicate_definition INO:0000042 IAO:0000115 a negative regulation process that down-regulates gene expression level ERROR duplicate_definition INO:0000095 IAO:0000115 a negative regulation process that down-regulates gene expression level ERROR duplicate_label INO:0000109 rdfs:label macrophage-pathogen interaction@en ERROR duplicate_label INO:0000146 rdfs:label macrophage-pathogen interaction@en ERROR missing_ontology_license http://purl.obolibrary.org/obo/ino.owl dc:license ERROR misused_obsolete_label INO:0000159 rdfs:label obsolete class@en WARN annotation_whitespace INO:0000002 IAO:0000115 Interaction is a processual entity that has two or more participants (i.e., interactors) that have an effect upon one another. @en WARN annotation_whitespace INO:0000003 IAO:0000115 an interaction network that includes at least two interactions and has a start point(s) and an end point(s). WARN annotation_whitespace INO:0000006 IAO:0000115 an annotation property that lists keyword(s) useful for literature tagging and retrieval of sentences containing the type (or kind) of entity (e.g., interaction) as shown by the ontology term label and definition. WARN annotation_whitespace INO:0000014 IAO:0000115 an edge is an object that represents a graphic line that links two interactors in an interaction. WARN annotation_whitespace INO:0000018 IAO:0000115 a biological interaction that occurs in the organism level. WARN annotation_whitespace INO:0000018 IAO:0000116 Examples: a bacterium interacts with a mouse, a cat interacts with a dog WARN annotation_whitespace INO:0000019 IAO:0000115 A two-way interaction is an interaction that includes two different directions among two interactors. WARN annotation_whitespace INO:0000024 IAO:0000115 a positive regulation that one interactor activates another. WARN annotation_whitespace INO:0000030 IAO:0000115 an interaction that involves a gene and its environment (e.g., calcium in blood). WARN annotation_whitespace INO:0000033 IAO:0000115 a negative regulation that attenuates the virulence of a pathogenic microbe. WARN annotation_whitespace INO:0000035 IAO:0000115 a phosphorylation process that adds a phosphate to a protein kinase (possibly affecting its activity) by virtue of its own enzymic activity. WARN annotation_whitespace INO:0000045 IAO:0000115 a gene expression process that results in protein production from a gene DNA sequence. WARN annotation_whitespace INO:0000050 IAO:0000115 an indirect association that one interactor competes with another interactor in a specfiic process. WARN annotation_whitespace INO:0000056 IAO:0000115 a gene expression that has decreased volume. WARN annotation_whitespace INO:0000058 IAO:0000115 a direct physical association that one interactor is converted from another interactor. WARN annotation_whitespace INO:0000059 IAO:0000115 an indirect association that one interactor cooperates with another interactor in a specfiic process. WARN annotation_whitespace INO:0000061 IAO:0000115 an indirect association that two interactors are correlated in a process without defined influence of each other. WARN annotation_whitespace INO:0000068 IAO:0000115 a regulation in which one interactor has a negative effect on another interactor WARN annotation_whitespace INO:0000068 IAO:0000116 YH: different types of negative regulations exist. These types are related to different qualities and phenotyes of regulated targets. WARN annotation_whitespace INO:0000073 IAO:0000115 a negative regulation that results in the decrease of one interactor volume. WARN annotation_whitespace INO:0000076 IAO:0000115 an enzymatic reaction that leads to the breakdown of a biochemical entity. WARN annotation_whitespace INO:0000084 IAO:0000115 a negative regulation that results in a destabilization. WARN annotation_whitespace INO:0000086 IAO:0000115 a regulation that one interactor has a dominant effect on the quality of another interactor. This differs from the accessory regulation. WARN annotation_whitespace INO:0000088 IAO:0000115 a protein complex assembly that involves two proteins that form a dimer. WARN annotation_whitespace INO:0000089 IAO:0000115 a regulation process that involves in two interactors co-regulate a third interactor. WARN annotation_whitespace INO:0000096 IAO:0000116 "YH: For example, \""IL-2 and IL-15 induced the production of IL-17 and IFN-γ in a dose dependent manner by PBMCs.” " WARN annotation_whitespace INO:0000102 IAO:0000115 a biological interaction that uses the information from a gene to synthesize a functional gene product. WARN annotation_whitespace INO:0000103 IAO:0000115 a positive regulation that one interactor facilitates a phenomenon such as a phenotype. This is an accessory effect not a major one. WARN annotation_whitespace INO:0000111 IAO:0000115 a protein dimerization where two proteins are different. WARN annotation_whitespace INO:0000112 IAO:0000115 a protein dimerization where two proteins are the same. WARN annotation_whitespace INO:0000114 IAO:0000115 a gene expression that has increased volume. WARN annotation_whitespace INO:0000117 IAO:0000116 YH: different types of positive regulations exist. These types are related to different qualities and phenotyes of regulated targets. WARN annotation_whitespace INO:0000122 IAO:0000115 a positive regulation that leads to the induction of a new interactor due to the presence of another interactor. WARN annotation_whitespace INO:0000126 IAO:0000115 a negative regulation that one interactor interferes a process. WARN annotation_whitespace INO:0000140 IAO:0000115 a biochemical reaction that one interactor neutrolizes another. WARN annotation_whitespace INO:0000148 IAO:0000115 an indirect association that one interactor is preceded by another interactor. WARN annotation_whitespace INO:0000155 IAO:0000115 a positive regulation that leads the recruitment of one interactor from one location to another. WARN annotation_whitespace INO:0000157 IAO:0000115 A regulation represents a regulatory interaction between two interactors. WARN annotation_whitespace INO:0000165 IAO:0000115 a postive interaction that one interactor increases the stability of another interactor. WARN annotation_whitespace INO:0000174 IAO:0000115 a cell-cell interaction that transfers viral, bacterial, or both bacterial and viral DNA from one cell to another using a bacteriophage vector. WARN annotation_whitespace INO:0000231 IAO:0000116 a correlation association that two genes are co-expressed in a system. WARN annotation_whitespace INO:0000234 IAO:0000115 a negative regulation that results in the deregulation of one interactor on a process. WARN annotation_whitespace INO:0000311 IAO:0000115 an interaction between two proteins. WARN duplicate_exact_synonym INO:0000067 IAO:0000118 negative protein activity regulation WARN duplicate_exact_synonym INO:0000104 IAO:0000118 negative protein activity regulation WARN duplicate_label_synonym INO:0000114 IAO:0000118 overexpression WARN equivalent_class_axiom_no_genus INO:0000008 RO:0000087 INO:0000005 WARN equivalent_class_axiom_no_genus INO:0000016 RO:0000087 INO:0000015 WARN equivalent_class_axiom_no_genus INO:0000017 RO:0000087 INO:0000011 WARN equivalent_class_axiom_no_genus INO:0000032 RO:0002211 INO:0000173 WARN equivalent_class_axiom_no_genus INO:0000034 RO:0002211 INO:0000045 WARN equivalent_class_axiom_no_genus INO:0000038 RO:0002213 INO:0000102 WARN equivalent_class_axiom_no_genus INO:0000039 RO:0002212 INO:0000102 WARN equivalent_class_axiom_no_genus INO:0000042 RO:0002212 INO:0000173 WARN equivalent_class_axiom_no_genus INO:0000043 RO:0002212 INO:0000045 WARN equivalent_class_axiom_no_genus INO:0000044 RO:0002211 INO:0000102 WARN equivalent_class_axiom_no_genus INO:0000047 RO:0000087 INO:0000069 WARN equivalent_class_axiom_no_genus INO:0000049 RO:0002213 INO:0000173 WARN equivalent_class_axiom_no_genus INO:0000053 RO:0002213 INO:0000045 WARN equivalent_class_axiom_no_genus INO:0000125 RO:0000087 INO:0000009 WARN equivalent_class_axiom_no_genus INO:0000141 RO:0000087 INO:0000134 WARN equivalent_class_axiom_no_genus INO:0000144 RO:0000087 INO:0000137 WARN equivalent_class_axiom_no_genus INO:0000151 RO:0000087 INO:0000010 WARN missing_definition INO:0000036 IAO:0000115 WARN missing_definition INO:0000041 IAO:0000115 WARN missing_definition INO:0000062 IAO:0000115 WARN missing_definition INO:0000066 IAO:0000115 WARN missing_definition INO:0000080 IAO:0000115 WARN missing_definition INO:0000082 IAO:0000115 WARN missing_definition INO:0000083 IAO:0000115 WARN missing_definition INO:0000090 IAO:0000115 WARN missing_definition INO:0000092 IAO:0000115 WARN missing_definition INO:0000110 IAO:0000115 WARN missing_definition INO:0000115 IAO:0000115 WARN missing_definition INO:0000117 IAO:0000115 WARN missing_definition INO:0000121 IAO:0000115 WARN missing_definition INO:0000123 IAO:0000115 WARN missing_definition INO:0000127 IAO:0000115 WARN missing_definition INO:0000128 IAO:0000115 WARN missing_definition INO:0000131 IAO:0000115 WARN missing_definition INO:0000132 IAO:0000115 WARN missing_definition INO:0000136 IAO:0000115 WARN missing_definition INO:0000139 IAO:0000115 WARN missing_definition INO:0000142 IAO:0000115 WARN missing_definition INO:0000149 IAO:0000115 WARN missing_definition INO:0000156 IAO:0000115 WARN missing_definition INO:0000159 IAO:0000115 WARN missing_definition INO:0000178 IAO:0000115 WARN missing_definition INO:0000231 IAO:0000115 INFO lowercase_definition INO:0000003 IAO:0000115 an interaction network that includes at least two interactions and has a start point(s) and an end point(s). INFO lowercase_definition INO:0000004 IAO:0000115 an interaction network model that is represented by a probabilistic graphical model (a type of statistical model) that represents a set of random variables and their conditional dependencies via a directed acyclic graph (DAG). INFO lowercase_definition INO:0000005 IAO:0000115 an regulator role that is borne by a material entity that regulates an interaction. INFO lowercase_definition INO:0000006 IAO:0000115 an annotation property that lists keyword(s) useful for literature tagging and retrieval of sentences containing the type (or kind) of entity (e.g., interaction) as shown by the ontology term label and definition. INFO lowercase_definition INO:0000007 IAO:0000115 a positive regulation that one interactor up-regulates another. INFO lowercase_definition INO:0000008 IAO:0000115 an interactor that regulates an interaction. INFO lowercase_definition INO:0000009 IAO:0000115 an interactor role that is borne by a material entity that acts as an input of an interaction. INFO lowercase_definition INO:0000010 IAO:0000115 an interactor role that is borne by a material entity that acts as an output of an interaction. INFO lowercase_definition INO:0000011 IAO:0000115 a positive regulator role that is borne by a material entity that activates an interaction. INFO lowercase_definition INO:0000012 IAO:0000115 an interaction network model that is represented by at least two mutual information interactions. INFO lowercase_definition INO:0000013 IAO:0000115 a node is an object that represents an interactor in a graph of an interaction or interaction network. INFO lowercase_definition INO:0000014 IAO:0000115 an edge is an object that represents a graphic line that links two interactors in an interaction. INFO lowercase_definition INO:0000015 IAO:0000115 a role that is borne by a material entity to act as a participant in an interaction process. INFO lowercase_definition INO:0000016 IAO:0000115 an interactor is a material entity that participates in an interaction. INFO lowercase_definition INO:0000017 IAO:0000115 a positive interaction regulator that activates an interaction. INFO lowercase_definition INO:0000018 IAO:0000115 a biological interaction that occurs in the organism level. INFO lowercase_definition INO:0000020 IAO:0000115 an object property between an activation process and a material entity that acts as an activator during the process. INFO lowercase_definition INO:0000021 IAO:0000115 a pathway that exists in human body. INFO lowercase_definition INO:0000022 IAO:0000115 an up-regulation that one interactor up-regulates the secretion of another interactor. INFO lowercase_definition INO:0000023 IAO:0000115 an interaction involving human molecules INFO lowercase_definition INO:0000024 IAO:0000115 a positive regulation that one interactor activates another. INFO lowercase_definition INO:0000025 IAO:0000115 an interaction that includes a gene and a cell as interactors. INFO lowercase_definition INO:0000026 IAO:0000115 an activation process where one protein is activated by a material entity INFO lowercase_definition INO:0000027 IAO:0000115 a biological interaction that involves two cells as interactors. INFO lowercase_definition INO:0000028 IAO:0000115 an activation process where one protein is activated by a gene mutant INFO lowercase_definition INO:0000029 IAO:0000115 a biochemical binding where a substance binds to the same site an agonist would bind to without causing activation of the receptor INFO lowercase_definition INO:0000030 IAO:0000115 an interaction that involves a gene and its environment (e.g., calcium in blood). INFO lowercase_definition INO:0000031 IAO:0000115 a regulation process that regulates the location of a protein INFO lowercase_definition INO:0000032 IAO:0000115 a gene expression regulation process that involves the regulation of a gene transcription. INFO lowercase_definition INO:0000033 IAO:0000115 a negative regulation that attenuates the virulence of a pathogenic microbe. INFO lowercase_definition INO:0000034 IAO:0000115 a gene expression regulation process that involves the regulation of a protein translation process. INFO lowercase_definition INO:0000035 IAO:0000115 a phosphorylation process that adds a phosphate to a protein kinase (possibly affecting its activity) by virtue of its own enzymic activity. INFO lowercase_definition INO:0000037 IAO:0000115 a regulation process that regulates the activation of a gene so that the gene is expressed at a particular time INFO lowercase_definition INO:0000038 IAO:0000115 a regulation process that positively regulates gene expression level INFO lowercase_definition INO:0000039 IAO:0000115 a regulation process that negatively regulates gene expression level INFO lowercase_definition INO:0000040 IAO:0000115 a human molecular reaction that is specifically a biochemical reaction INFO lowercase_definition INO:0000042 IAO:0000115 a negative regulation process that down-regulates gene expression level INFO lowercase_definition INO:0000043 IAO:0000115 a negative regulation process that down-regulates protein translation level INFO lowercase_definition INO:0000044 IAO:0000115 a regulation process that regulates gene expression level INFO lowercase_definition INO:0000045 IAO:0000115 a gene expression process that results in protein production from a gene DNA sequence. INFO lowercase_definition INO:0000046 IAO:0000115 a negative regulation of gene transcription process that specifiies the negative regulation being an inhibition. INFO lowercase_definition INO:0000047 IAO:0000115 an interactor that starts or speeds up a chemical reaction while undergoing no permanent change itself. INFO lowercase_definition INO:0000048 IAO:0000115 a coprecipitation that occurs through an immunoprecipitation process. INFO lowercase_definition INO:0000049 IAO:0000115 a regulation of transcription process that inviolves a positive regulation. INFO lowercase_definition INO:0000050 IAO:0000115 an indirect association that one interactor competes with another interactor in a specfiic process. INFO lowercase_definition INO:0000051 IAO:0000115 a positive regulation of gene transcription process that inviolves an activation of the gene transcription. INFO lowercase_definition INO:0000052 IAO:0000115 an activation of gene transcription that is achieved by a low level of a protein INFO lowercase_definition INO:0000053 IAO:0000115 a regulation of translation process that positively regulates protein translation level INFO lowercase_definition INO:0000054 IAO:0000115 a direct interaction where an antigen interacts with an antibody physically. INFO lowercase_definition INO:0000055 IAO:0000115 a regulation process that regulates an activity of a protein INFO lowercase_definition INO:0000056 IAO:0000115 a gene expression that has decreased volume. INFO lowercase_definition INO:0000057 IAO:0000115 a regulation that one interactor controls the quality of another interactor to a specific range INFO lowercase_definition INO:0000058 IAO:0000115 a direct physical association that one interactor is converted from another interactor. INFO lowercase_definition INO:0000059 IAO:0000115 an indirect association that one interactor cooperates with another interactor in a specfiic process. INFO lowercase_definition INO:0000060 IAO:0000115 a colocalization that two interactors are precipitated together. INFO lowercase_definition INO:0000061 IAO:0000115 an indirect association that two interactors are correlated in a process without defined influence of each other. INFO lowercase_definition INO:0000063 IAO:0000115 an interaction that involves a cell and its environment as interactors INFO lowercase_definition INO:0000064 IAO:0000115 an immuno-precipitation that one interactor is precipitated based on an cross- immunological precipitation process. INFO lowercase_definition INO:0000065 IAO:0000115 an interaction that involves an organism and its environment as interactors INFO lowercase_definition INO:0000067 IAO:0000115 a regulation of protein activitiy process that involves a negative regulation INFO lowercase_definition INO:0000068 IAO:0000115 a regulation in which one interactor has a negative effect on another interactor INFO lowercase_definition INO:0000069 IAO:0000115 an interactor role that is played by a material entity that starts or speeds up a chemical reaction while undergoing no permanent change itself. INFO lowercase_definition INO:0000070 IAO:0000115 a negative regulation of protein activitiy process that involves an inhibition of a protein activity INFO lowercase_definition INO:0000071 IAO:0000115 a regulation of transcription process that occurs through the binding to a promotor of a gene INFO lowercase_definition INO:0000072 IAO:0000115 a regulation of transcription by binding to promoter that is further classified as a positive regulation INFO lowercase_definition INO:0000073 IAO:0000115 a negative regulation that results in the decrease of one interactor volume. INFO lowercase_definition INO:0000074 IAO:0000115 a regulation of transcription by binding to promoter that is further classified as a positive regulation INFO lowercase_definition INO:0000075 IAO:0000115 a positive regulation of gene expression process that activates a gene so that the gene is expressed at a particular time INFO lowercase_definition INO:0000076 IAO:0000115 an enzymatic reaction that leads to the breakdown of a biochemical entity. INFO lowercase_definition INO:0000077 IAO:0000115 a regulation of transcription process where two or more regulators regulate a gene transcription INFO lowercase_definition INO:0000078 IAO:0000115 an activation of gene transcription that is achieved by a high level of a protein INFO lowercase_definition INO:0000079 IAO:0000115 a regulation of transcription process through binding to a promoter or regulating the promoter binding activity INFO lowercase_definition INO:0000081 IAO:0000115 an activation of gene transcription that is achieved by a phosphorylated protein INFO lowercase_definition INO:0000084 IAO:0000115 a negative regulation that results in a destabilization. INFO lowercase_definition INO:0000085 IAO:0000115 a negative regulation process that inhibits gene expression level INFO lowercase_definition INO:0000086 IAO:0000115 a regulation that one interactor has a dominant effect on the quality of another interactor. This differs from the accessory regulation. INFO lowercase_definition INO:0000087 IAO:0000115 an annotation property that specifies the dependency pattern of the literature keywords that match to the ontology interaction type. INFO lowercase_definition INO:0000088 IAO:0000115 a protein complex assembly that involves two proteins that form a dimer. INFO lowercase_definition INO:0000089 IAO:0000115 a regulation process that involves in two interactors co-regulate a third interactor. INFO lowercase_definition INO:0000091 IAO:0000115 a negative regulation that results in a disruption. INFO lowercase_definition INO:0000093 IAO:0000115 a negative regulation that one interactor down-regulates another. INFO lowercase_definition INO:0000094 IAO:0000115 a positive regulation of gene expression process that up-regulates gene expression level INFO lowercase_definition INO:0000095 IAO:0000115 a negative regulation process that down-regulates gene expression level INFO lowercase_definition INO:0000096 IAO:0000115 an induction that leads to the production of an entity INFO lowercase_definition INO:0000097 IAO:0000115 a negative regulation that one interactor eliminates another. INFO lowercase_definition INO:0000098 IAO:0000115 a cell-cell interaction that the transfers genetic material between bacterial cells by direct cell-to-cell contact or by a bridge-like connection between two cells. INFO lowercase_definition INO:0000100 IAO:0000115 a regulation process where one gene product regulates an assembly process which forms an assembly having another gene product. INFO lowercase_definition INO:0000101 IAO:0000115 a human molecular interaction where one molecule controls another molecule. INFO lowercase_definition INO:0000102 IAO:0000115 a biological interaction that uses the information from a gene to synthesize a functional gene product. INFO lowercase_definition INO:0000103 IAO:0000115 a positive regulation that one interactor facilitates a phenomenon such as a phenotype. This is an accessory effect not a major one. INFO lowercase_definition INO:0000104 IAO:0000115 a regulation of protein activitiy process that involves a positive regulation INFO lowercase_definition INO:0000106 IAO:0000115 a genetic interaction that forms a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion. INFO lowercase_definition INO:0000108 IAO:0000115 an induction that is achieved by binding to a protein INFO lowercase_definition INO:0000111 IAO:0000115 a protein dimerization where two proteins are different. INFO lowercase_definition INO:0000112 IAO:0000115 a protein dimerization where two proteins are the same. INFO lowercase_definition INO:0000114 IAO:0000115 a gene expression that has increased volume. INFO lowercase_definition INO:0000116 IAO:0000115 a translocation that one interactor is precipitated based on an immunological precipitation process. INFO lowercase_definition INO:0000119 IAO:0000115 a negative regulation that one interactor inactivates another. INFO lowercase_definition INO:0000120 IAO:0000115 a positive regulation that leads to the increase of a quality of an entity. INFO lowercase_definition INO:0000122 IAO:0000115 a positive regulation that leads to the induction of a new interactor due to the presence of another interactor. INFO lowercase_definition INO:0000124 IAO:0000115 a negative regulation that one interactor inhibites another. INFO lowercase_definition INO:0000125 IAO:0000115 an interactor that is an input of an interaction.