ROBOT Report - vo

VO:0000018

A Brucella abortus vaccine that expresses Cu/Zn SOD with DNA plasmid pcDNA.

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VO:0000035

a vaccinia virus vaccine that is a freeze-dried calf lymph smallpox vaccine, specifically, Dryvax is a live-virus preparation of vaccinia prepared from calf lymph.

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VO:0000048

YL

3

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VO:0000048

ZX

4

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VO:0000069

A Measles-Mumps-Rubella vaccine that is live attenuated and manufactured by Merck & Co, Inc.

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VO:0000070

A Measles-Mumps vaccine that is manufactured by Merck and used for human.

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VO:0000079

an influenza vaccine that is similar to Fluzone but has high dose.

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VO:0000091

A Measles-Mumps-Rubella-Vericella vaccine that is live and manufactured by Merck & Co, Inc.

8

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VO:0000137

A vaccine role that indicates the vaccine being a combination vaccine.

9

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VO:0000145

a vaccine component role that inheres in a recombit vaccine vector as a vaccine component. The combination of a recombit vaccine vector and a heterogenous protective antigen(s) inserted inside the vector for a recombit vector vaccine.

10

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VO:0000147

an adjuvant role that inheres in a vaccine component which is added as part of a vaccine and induces enhanced adaptive immune response to the vaccine antigen.

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VO:0000154

A Brucella abortus gene that has the name sodC and comes from strain 2308.

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VO:0000166

a vaccine vector that uses a live bacterium as the vector

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VO:0000194

a USA licensed vaccine role that inheres ina vaccine approven to be by the US FDA to be used for humans in the USA.

14

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VO:0000207

A vaccine contraindication is a contraindication that increases the risks of a vaccination.

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VO:0000208

A vaccine role that is not licensed or in clinical trial; instead, it has been experimently approved to induce protection or treatment effect in vivo in at least an experimental animal model.

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VO:0000211

an organismal quality of a whole organism vaccine where the whole organism is inactivated/killed and lacks the capability of replication.

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VO:0000310

a vaccine additive that stabilizes the vaccine emulsification manufacturing process and makes emulsion of the vaccine easier.

18

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VO:0000335

A vaccination site that is used for injection of a vaccine.

19

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VO:0000369

A 'has vaccine component' relation that specifies the plasmid used for development of a particular DNA vaccine.

20

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VO:0000375

IAO:0000112

'Mycobacterium avium relA mutant vaccine' includes a gene mutation of relA from virulent Mycobacterium avium.

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VO:0000384

PMID:18472194

22

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VO:0000400

A vaccine that contains one vaccine for priming and at least one other vaccine for boosting.

23

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VO:0000401

A prime-boost vaccine that contains one DNA vaccine for priming and at least one other vaccine for boosting.

24

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VO:0000435

a vaccine component that is composed of a plasmid and used in the generation of a DNA vaccine.

25

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VO:0000441

Role of a material entity in an investigation, which has not been experimentally or clinically verified to induce a protection or treatment in vivo in a recipient organism.

26

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VO:0000465

a S. aureus vaccine that uses bacterin as the protective antigen.

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VO:0000467

a S. aureus vaccine that uses the bacterial phage lysate as the protective antigen.

28

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VO:0000469

a bacterial vaccine that uses bacterin from a bacterial strain isolated from a herd with a purpose to generate hard-specific vaccine.

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VO:0000470

an autogenous bacterin vaccine that is prepared for poultry use.

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VO:0000476

A 'has vaccine component' relation that specifies a gene inserted to DNA vaccine plasmid for development of a particular DNA vaccine, and this gene encodes for a protein antigen.

31

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VO:0000483

A subunit vaccine that is made using a part of whole organism as subunit for vaccine development.

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VO:0000504

a vaccine role that indicates the vaccine being a whole organism vaccine.

33

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VO:0000512

a viral vaccine against a disease caused by a virus belong to Poxviridae.

34

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VO:0000524

IAO:0000116

This relation only works for those vaccine antigen that is physically part of a vaccine preparation. It does not include those antigens that are not part of vaccine. For example, a protein antigen expressed in a DNA vaccine is not a part of vaccine pe ser. In this case, the vaccine expresses the protein, but the gene is part of the vaccine, not the protein. For the case, we can use the relation 'DNA vaccine expresses protein antigen' under the relation 'expresses'.

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VO:0000532

A route of administration that is loacted in the hypodermis (subcutaneous tissue) region.

36

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VO:0000560

A toxin is a poisonous substance produced within living cells or organisms; man-made substances created by artificial processes are thus excluded.

37

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VO:0000574

A path that is located in gross anatomical part of an organism (e.g., human) and is used for administering a vaccine, a drug, fluid, poison, or other substance into the body.

38

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VO:0000577

A subunit vaccine that uses small peptide(s) as immunoepitopes.

39

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VO:0000599

IAO:0000116

a vaccine component that uses a microbe (e.g., bacterium, virus, and parasitic organism) as a vector that is inserted with the DNA(s) of a heterologous protective antigen(s) to generate a \"recombit vector vaccine\". The microorganism used as a vector generally has a stable non or low pathogenic phenotype for the species the vaccine is intended for.

40

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VO:0000608

An 'expresses' relation that specifies a relation between a DNA vaccine and a protein antigen to be expressed by the DNA vaccine.

41

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VO:0000615

Role that inheres in a prepared material entity that is designed to induce protection or treatment for a disease or infection.

42

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VO:0000617

A role that inheres in a material entity that becomes an ingredient of a vaccine.

43

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VO:0000622

a vaccine antigen role that inheres in a vaccine antigen which is capable of inducing protective immunity.

44

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VO:0000623

A vaccine role that indicates the vaccine being a DNA vaccine.

45

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VO:0000624

A vaccine role that indicates the vaccine being a subunit vaccine.

46

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VO:0000625

A vaccine role that indicates the vaccine being a conjugate vaccine.

47

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VO:0000636

A vaccine role that indicates the vaccine being a recombit vector vaccine.

48

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VO:0000671

A Salmonella vaccine against typhoid fever (or called typoid), caused by Salmonella enterica enterica, serovar Typhi.

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VO:0000675

a Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases.

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VO:0000685

a recombit vector vaccine role that inheres in a bacterium that carries a vaccine antigen for development of a particular vaccine

51

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VO:0000692

A subunit vaccine role that indicates the vaccine being a peptide vaccine.

52

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VO:0000702

a recombit vector vaccine role that inheres in a virus that carries a vaccine antigen for development of a particular vaccine

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VO:0000728

A vaccine role that indicates the vaccine being a RNA vaccine.

54

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VO:0000767

A bacterial vaccine that protects against diseases caused by various species of Rickettsia. Typhus is any of several similar diseases caused by Rickettsia bacteria. So Rickettsial vaccine is also called typhus vaccine.

55

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VO:0000794

A Brucella abortus gene that has the name wboA and comes from strain 2308.

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VO:0000799

An object property that represents a mutational relation between a vaccine organism and another material (e.g., gene or protein). the mutated material initially exists in the original wildtype organism.

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VO:0000807

A vaccine role that indicates the vaccine being a toxoid vaccine.

58

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VO:0000818

An object property that specifies a relation between a vaccine and a vaccine virmugen.

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VO:0000922

a vaccine stablizer that is based on monosodium glutamate.

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VO:0000931

a cell culture residual in vaccine that is residual protein from cell culture.

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VO:0000957

a B. abortus vaccine that uses a recombit vector.

62

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VO:0001014

a live attenuated quality of a bacterial vaccine strain.

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VO:0001015

a live attenuated quality of a virus vaccine strain.

64

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VO:0001019

an avian reovirus vaccine that using live attenauted reovirus.

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VO:0001021

a feline panleukopenia virus vaccine where the virus used is live attenuated.

66

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VO:0001028

a parasite vaccine vector using a live attenuated Leishmania tarentolae strain.

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VO:0001050

IAO:0000118

PrV vaccine vector

68

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VO:0001060

IAO:0000118

NDV vaccine vector

69

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VO:0001084

a viral vaccine vector that uses a baculovirus as the vector

70

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VO:0001107

a vaccinia virus vector that uses the Modified Vaccinia Ankara (MVA) virus.

71

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VO:0001109

a vaccinia virus vector that uses the MVTT vaccine strain as the vector. MVTT is an attenuated vaccine strain.

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VO:0001111

A poxvirus vaccine vector that uses an attenuated lumpy skin disease virus as the vector.

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VO:0001128

a canarypox vaccine vector that uses an attenuated canarypox virus strain ALVAC. The ALVAC vector is a canarypox virus clone obtained after four rounds of plaque purification of a strain from a vaccine for canaries.

74

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VO:0001186

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

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VO:0001188

A measurement datum that represents a vaccine strain. Different strains can be represented using distinct digital numbers.

76

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VO:0001188

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

77

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VO:0001189

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

78

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VO:0001190

A measurement datum that indicates the usage of a vaccine adjuvant. Different digital numbers can be used to represent different adjuvants.

79

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VO:0001190

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

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VO:0001191

A measurement datum that represents a specific protective antigen used in a vaccine. The antigen can be represented by a described digit.

81

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VO:0001191

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

82

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VO:0001192

A measurement datum that represents a specific mutated gene from a vaccine strain. The mutated can be represented by a described digit.

83

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VO:0001192

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

84

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VO:0001193

A measurement datum that represents a specific mouse strain used for vaccination. Different strains can be represented using discretized digitals. For example, 0 = BALB/c; 1 = CD1; 2 = mixed/outbred; 3 = C57BL/6; 4 = OF1; 5 = 129/Sv; 6 = Swiss albino.

85

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VO:0001193

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

86

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VO:0001194

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

87

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VO:0001195

A measurement datum that represents a specific route (e.g., i.p.) used for vaccination. Different routes can be represented using discretized digitals. 0 = IP; 1 = PO; 2 = SC; 3 = IM; 4 = IN; 6 = IG; 7 = IV; 8 = ID.

88

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VO:0001195

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

89

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VO:0001196

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

90

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VO:0001197

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

91

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VO:0001198

A measurement datum that represents a specific pathogen strain used for animal challenge study. Different pathogen strains can be represented using discretized digitals.

92

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VO:0001198

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

93

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VO:0001199

A measurement datum that represents a specific pathogen used for animal challenge study. Different pathogens can be represented using discretized digitals.

94

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VO:0001199

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

95

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VO:0001202

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

96

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VO:0001203

A measurement datum that represents a length of days as the interval between a vaccination and a challenge in a specific vaccine protection study.

97

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VO:0001203

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

98

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VO:0001204

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

99

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VO:0001205

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

100

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VO:0001206

Todd TE, Tibi O, Lin Y, Sayers S, Bronner DN, Xiang Z, He Y. Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates. BMC Bioinformatics. 2013, 14(Suppl 6):S3. PMID: 23735014. PMCID: PMC3633026.

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VO:0001214

a bacterial vaccine that uses inactivated bacterial organism.

102

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VO:0001215

an anti-reproductive vaccine for cattle. The vaccine is based on the established principle that antibodies to the hypothalamic releasing hormone, gonadotrophin releasing hormone (GnRH) block the action of GnRH on pituitary secretion of luteinizing hormone and follicle stimulating hormone, leading to gonadal atrophy in mammals. The vaccine comprises an immunogenic GnRH:ovalbumin conjugate formulated in a novel double adjuvant system and is administered in a two-dose treatment regimen.

103

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VO:0001380

Oliver He

104

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VO:0001384